The Effects of Antidepressants on Lordosis Behavior in Female Rats Exposed to Stress
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In the current study, a role for 5-HT3 receptors in the control of lordosis behavior was examined under conditions of acute stress. Furthermore, under the same conditions, the effects of activation of second messenger systems on lordosis behavior were also examined. Outcomes from these studies suggest that exposure to acute noise stress did not inhibit sexual behavior in proestrus female rats. When the effects of different doses of the 5-HT3 receptor antagonist, tropisetron, were examined, proestrus females not exposed to stress appeared to show a slight decline in lordosis. In contrast, proestrus females exposed to stress were less inhibited after tropisetron treatment. Similar to the intact rats, tropisetron treatment in ovariectomized female rats hormonally primed with both estrogen and progesterone not exposed to stress, caused a slight decline in lordosis when compared to the stressed group. After exposure to noise stress, treatment with tropisetron appeared to cause a greater decline in lordosis in rats primed with estrogen alone. This inhibitory response to tropisetron after estrogen alone was attenuated when rats were primed with both estrogen and progesterone. In proestrus females, treatment with 2.0 mg/kg inositol and exposure to noise stress caused a greater decline in L/M ratio. There was a smaller decline in rats treated with 2.0 mg/kg inositol and not exposed to noise stress. In contrast, treatment with 1.0 mg/kg inositol and exposure to stress caused a smaller decline in lordosis behavior in comparison to the non-stress group. The results of this group were similar to that of all doses of tropisetron. These studies implicate specific roles of estrogen/progesterone in the regulation of lordosis behavior under stressed conditions in female rats.
Franklin and Marshall College Archives, Undergraduate Honors Thesis 2005
- F&M Theses Collection