Potential Interactions Between Ovarian Hormones and the Serotonin-3 in Ovariectomized Female Rats Exposed to the Forced Swim Test.
In order to evaluate a potential interaction between female hormones, estrogen (E) and progesterone (P), and the 5-HT3 receptors, we investigated the effects of a 5-HT3 receptor antagonist in a behavioral model of despair, the forced swim test (FST). In agreement, in this model and in previous studies, estrogen treatment significantly decreased the duration of immobility by increasing the duration of swimming. Progesterone treatment failed to modify any of the behaviors examined. However, treatment with tropisetron did increase immobility behaviors in the FST. The unexpected increase in immobility after treatment with 1.0 ing/kg tropisetron was attributed to the allosteric binding interactions between estrogen and progesterone on the 5-HT3 receptors and possible involvement of dopamine via progesterone metabolites and the 5-HT3 receptors.
Franklin and Marshall College Archives, Undergraduate Honors Thesis 2007
- F&M Theses Collection