Does gender influence the effect of intermittent stress on amphetamine-induced sensitization in adult rats?
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Bhagat, Sarah M.
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The present study investigated gender differences in locomotor behavior and stereotypy produced by intermittent amphetamine treatments. This study also determined if stress and amphetamine interchangeably cause sensitization and if gender differences existed in this phenomenon. It was found that female rats showed more locomotor activity and stereotypy than male rats. In addition, prior exposure to amphetamine caused an increase of stereotypic behavior. Gender influences on stereotypy are likely caused by gonadal hormones, such as estrogen, a female hormone that increases the release of dopamine. High levels of dopamine increase movement. Amphetamine induces movement and stereotypy through a similar mechanism, in which it increases the release of dopamine from dopaminergic pathways in the nigrostriatal and mesolimbic systems.
Franklin and Marshall College Archives, Undergraduate Honors Thesis 2007
- F&M Theses Collection